In other words, the positive health benefits associated with I3C are actually a result of its conversion to the more “bio-active” DIM. I3C itself remains inactive in the body, but after its conversion to DIM, it helps inhibit aromatase to decrease free-floating estradiol estrogen (E2) levels. I3C converts into DIM during digestion, which is then released into the bloodstream to work its magic on aromatase enzymes, SHBG-bound testosterone, and unmetabolized estrogen metabolites. The main reason: I3C works primarily as a precursor to DIM. Yet, despite their similarities, DIM is the preferred supplement choice over I3C. Indole-3-CarbinolĪs we already mentioned, DIM is derived from I3C–both being natural compounds found in Brassica vegetables both believed to reduce the risk factors associated with negative estrogen-influenced conditions. By Coyau / Wikimedia Commons, via Wikimedia Commons Diindolylmethane vs. Unfortunately, under certain circumstances, the opposite seems to also hold true. 2ĭuring an in-depth analysis of DIM’s metabolic and hormonal processes, researchers found that DIM might possess significant regulatory effects on testosterone & estrogen levels, potentially increasing active testosterone while reducing harmful, unmetabolized estrogens. Originally studied for its anti-inflammatory properties on respiratory inflammation, DIM was later found to have anti-viral and immune-boosting properties, which lead to DIM being clinically studied for the treatment and prevention of multiple forms of immune deficiency conditions and viral/bacterial infections. You know this species of vegetable through broccoli, but it also includes red cabbage, mustard greens, bok choy, horseradish, watercress, kale, and many others. ![]() Regulates levels of “bad” and “good” estrogens.ĭiindolylmethane (DIM) is the primary active metabolic compound derived from Indole-3 Carbinol (I3C), a chemical found in many vegetables of the Brassica family.Releases and safeguards T from T-binding carrier proteins.DIM’s Possible T-Boosting Bio-Activities."DIM slows down the conversion of testosterone into estrogen, so you'll have fewer symptoms of estrogen dominance. "Too much estrogen can lead to irregular, heavy periods, weight gain, problems sleeping, fatigue, depression or irritability, and a low libido," says Cheung. ![]() Helps mitigate estrogen dominance: Cheung notes that estrogen dominance can result from poor liver detoxification or obesity, as fat tissue will metabolize testosterone into estrogen. External factors such as birth control, excess meat and dairy, plastics, and other toxins may also contribute to estrogen dominance and resulting symptoms."Since DIM balances estrogen metabolism and receptor activity, and stimulates cellular detoxification, it may help support the prevention of various cancers, including breast, uterine, cervical, and prostate cancers," says Cheung. ![]()
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